Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7218557 | 0.89 | CRHR1 (0.40) | CRHR1ALDH1A1TSHR | |
| SCHEMBL7625265 | 0.88 | CRHR1 (0.36) | CRHR1ALDH1A1TSHRLMNAMEN1 | |
| SCHEMBL3444048 | 0.81 | CYP1A2 (0.33) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| SCHEMBL7216722 | 0.72 | CRHR1 (0.54) | CRHR1KDM4E | |
| SCHEMBL7216710 | 0.71 | PDK2 (0.33) | CRHR1KDM4EHPGD | |
| SCHEMBL21159079 | 0.70 | MEN1 (0.33) | ALDH1A1LMNAMEN1KMT2AKDM4E | |
| SCHEMBL7480702 | 0.70 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL12355610 | 0.69 | CRHR1 (0.34) | CRHR1ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL21886137 | 0.67 | CRHR1 (0.52) | CRHR1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL21886138 | 0.67 | LMNA (0.43) | CRHR1ALDH1A1TSHRLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258809-B1 | NERVOUS SYSTEM DISORDERS, ANTIDEPRESSANTS AND PSYCHIATRY | DUPONT PHARMACEUTICALS COMPANY | 2001-07-10 | — | — | US | disclosed |
| US-6124300-A | Aryloxy- and arylthio- fused pyridines and pyrimidines and derivatives | DUPONT PHARMACEUTICALS (US) | 2000-09-26 | — | — | US | disclosed |