Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2920989 | 1.00 | ESR1 (0.47) | ESR1ESR2ADRB2ALDH1A1L3MBTL1 | |
| SCHEMBL7939324 | 1.00 | ESR1 (0.47) | ESR1ESR2ADRB2ALDH1A1L3MBTL1 | |
| SCHEMBL1095072 | 0.83 | ESR1 (0.48) | ESR1ESR2ADRB2ALDH1A1L3MBTL1 | |
| SCHEMBL11229208 | 0.80 | GAA (0.42) | ESR1ESR2ADRB2ALDH1A1L3MBTL1 | |
| SCHEMBL9419163 | 0.78 | ADRB2 (0.46) | ADRB2GAAFFAR2TSHRMAPK1 | |
| SCHEMBL10952365 | 0.78 | ESR1 (0.47) | ESR1ESR2ALDH1A1GAAHPGD | |
| SCHEMBL10706998 | 0.78 | ESR1 (0.75) | ESR1ESR2ALDH1A1TDP1LMNA | |
| SCHEMBL7967104 | 0.78 | ESR1 (0.47) | ESR1ESR2ALDH1A1TDP1LMNA | |
| SCHEMBL11070316 | 0.78 | SLC6A3 (0.47) | ESR1ESR2ALDH1A1LMNAIDO1 | |
| SCHEMBL10573002 | 0.77 | SLC6A3 (0.41) | ESR1ESR2ADRB2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251650-B1 | Pseudomonas putida amidase polypeptide useful for the production of chiral amides and acids | E. I. DU PONT DE NEMOURS AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-6133421-A | FOR PRODUCTION OF AGROCHEMICALS AND PHARMACEUTICALS | E. I. DU PONT DE NEMOURS & COMPANY (US) | 2000-10-17 | — | — | US | disclosed |
| US-5888785-A | USING NUCLEIC ACID ISOLATED FROM PEUDOMONAS AS CATALYST | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5811286-A | Nucleic acid fragments encoding stereospecific nitrile hydratase and amidase enzymes and recombinant organisms expressing those enzymes useful for the production of chiral amides and acids | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-09-22 | — | — | US | disclosed |
| EP-0853663-A1 | NUCLEIC ACID FRAGMENTS ENCODING STEREOSPECIFIC NITRILE HYDRATASE AND AMIDASE ENZYMES AND RECOMBINANT MICROORGANISMS EXPRESSING THOSE ENZYMES USEFUL FOR THE PRODUCTION OF CHIRAL AMIDES AND ACIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997012964-A2 | NUCLEIC ACID FRAGMENTS ENCODING STEREOSPECIFIC NITRILE HYDRATASE AND AMIDASE ENZYMES AND RECOMBINANT MICROORGANISMS EXPRESSING THOSE ENZYMES USEFUL FOR THE PRODUCTION OF CHIRAL AMIDES AND ACIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1997-04-10 | — | — | WO | disclosed |