Oxirane

Oxirane

SCHEMBL7945897

C1CO1.O=C(O)ON1C(=O)CCC1=O

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 5/20 0.35
PARL Q9H300 2/20 0.33
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
TSHR P16473 1/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA9 Q16790 1/20 0.31
ALOX12 P18054 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL57128 0.91 PARL (0.38) MGLLPARLCA12CA1CA9
Bicarbonate SCHEMBL28277654 0.89 MGLL (0.36) MGLLPARLCA12CA1CA9
Hno SCHEMBL15321628 0.86 MGLL (0.36) MGLLPARLCA12CA1CA9
SCHEMBL15321160 0.86 MGLL (0.36) MGLLPARLCA12CA1CA9
SCHEMBL6352069 0.84 MGLL (0.32) MGLL
Methylene Chloride SCHEMBL28985432 0.83 MGLL (0.36) MGLLPARLALDH1A1CA12CA1
Ethylene Glycol SCHEMBL2577550 0.83 MGLL (0.34) MGLLPARLALDH1A1CA12CA1
SCHEMBL6346398 0.81 MGLL (0.31) MGLL
Propylene Oxide SCHEMBL19463228 0.80 MGLL (0.33) MGLLPARL
Propylene Oxide SCHEMBL19463234 0.80 MGLL (0.33) MGLLPARL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6180007-B1 GRAFT POLYMER; ACRYLONITRILE AND POLYETHER UNITS NEUROTECH, SA (FR) 2001-01-30 US disclosed
EP-0746582-B1 MEMBRANE FORMED BY AN ACRYLONITRILE-BASED POLYMER CYTOTHERAPEUTICS INC (US) 2000-03-15 EP disclosed
US-5720969-A GRAFT POLYMER FORMED BY REDUCING NITRILE GROUPS OF ACRYLONITRILE POLYMER AND GRAFTING POLYOXYALKYLENE OXIDE POLYMER CHAINS ONTO REACTIVE SITES FORMED CYTOTHERAPEUTICS, INC. (US) 1998-02-24 US disclosed
EP-0746582-A4 MEMBRANE FORMED BY AN ACRYLONITRILE-BASED POLYMER CYTOTHERAPEUTICS INC (US) 1997-12-29 EP disclosed
EP-0746582-A1 MEMBRANE FORMED BY AN ACRYLONITRILE-BASED POLYMER CYTOTHERAPEUTICS, INC. (US) 1996-12-11 EP disclosed
WO-1994025503-A9 MEMBRANE FORMED BY AN ACRYLONITRILE-BASED POLYMER 1994-12-22 WO disclosed
WO-1994025503-A1 MEMBRANE FORMED BY AN ACRYLONITRILE-BASED POLYMER CYTOTHERAPEUTICS, INC. (US) 1994-11-10 WO disclosed