Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 12/20 | 0.60 |
| ▸ | CCR4 | P51679 | 5/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387249 | 0.88 | EDNRA (0.66) | EDNRACCR4ABCB11 | |
| SCHEMBL1387150 | 0.87 | EDNRA (0.77) | EDNRACCR4ABCB11 | |
| SCHEMBL7939786 | 0.85 | EDNRA (0.58) | EDNRACCR4ABCB11 | |
| SCHEMBL1387397 | 0.85 | EDNRA (0.67) | EDNRACCR4ABCB11 | |
| SCHEMBL7949490 | 0.83 | EDNRA (0.58) | EDNRACCR4ABCB11 | |
| SCHEMBL1387336 | 0.83 | CCR4 (0.66) | EDNRACCR4ABCB11 | |
| SCHEMBL795555 | 0.83 | EDNRA (0.66) | EDNRACCR4ABCB11 | |
| SCHEMBL1387310 | 0.81 | EDNRA (0.81) | EDNRACCR4ABCB11 | |
| SCHEMBL7361201 | 0.78 | ABCB11 (0.67) | EDNRACCR4ABCB11 | |
| SCHEMBL7398790 | 0.77 | ABCB11 (0.71) | EDNRACCR4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749964-A1 | N-Heterocyclyl biphenyl sulfonamides | ZENECA LIMITED (GB) | 1996-12-27 | — | — | EP | claimed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| US-5668137-A | N-heterocyclic sulfonamides having endothelin receptor activity | ZENECA LTD. (GB) | 1997-09-16 | — | — | US | disclosed |