SCHEMBL7946078

SCHEMBL7946078

Nc1ccnc2c1nc(-c1nccs1)c(=O)n2C1CCC1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 7/20 0.36
ALDH1A1 P00352 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 2/20 0.35
CYP2C9 P11712 2/20 0.35
HPGD P15428 2/20 0.35
CASP1 P29466 2/20 0.35
CASP7 P55210 2/20 0.35
HSD17B10 Q99714 2/20 0.35
TSHR P16473 1/20 0.35
ADORA2A P29274 7/20 0.35
ADORA3 P0DMS8 3/20 0.34
ADORA2B P29275 3/20 0.34
AKT1 P31749 3/20 0.34
MTOR P42345 3/20 0.34
GRM1 Q13255 3/20 0.34
HSP90AA1 P07900 1/20 0.34
MEN1 O00255 1/20 0.34
USP2 O75604 1/20 0.34
GLA P06280 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3227759 0.95 ALDH1A1 (0.39) ADORA1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL7938180 0.79 AKT1 (0.41) ALDH1A1CYP1A2CYP3A4CYP2C9HPGD
SCHEMBL7938054 0.79 AKT1 (0.41) ADORA1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL7947925 0.79 ADORA1 (0.36) ADORA1ADORA2AADORA3ADORA2BHSP90AA1
SCHEMBL7946737 0.78 ALDH1A1 (0.36) ADORA1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL3227758 0.77 CYP1A2 (0.41) ADORA1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL7938419 0.77 AKT1 (0.41) ALDH1A1CYP1A2CYP3A4CYP2C9HPGD
SCHEMBL7938052 0.77 CCND1 (0.38) ALDH1A1CYP1A2CYP3A4CYP2C9HPGD
SCHEMBL7938413 0.76 CYP1A2 (0.44) ALDH1A1CYP1A2CYP3A4CYP2C9HPGD
SCHEMBL7937482 0.75 CYP1A2 (0.46) ALDH1A1CYP1A2CYP3A4CYP2C9HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010008775-A1 AMINOPYRIDOPYRAZINONE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES LIGAND PHARMACEUTICALS INC. (US) 2010-01-21 WO disclosed