Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 6/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HK1 | P19367 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7948386 | 0.97 | MAPT (0.37) | MAPTRAB9AL3MBTL1MEN1KMT2A | |
| Fluoride Ion SCHEMBL7937209 | 0.97 | RAB9A (0.40) | MAPTRAB9AL3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1185945 | 0.97 | MAPT (0.37) | MAPTRAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL29176 | 0.97 | MAPT (0.39) | MAPTRAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL29361524 | 0.97 | MAPT (0.39) | MAPTRAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL9116348 | 0.93 | MAPT (0.37) | MAPTRAB9AL3MBTL1MEN1KMT2A | |
| Iodide SCHEMBL7946268 | 0.93 | MAPT (0.37) | MAPTRAB9AL3MBTL1MEN1KMT2A | |
| Bromide SCHEMBL7948384 | 0.93 | MAPT (0.37) | MAPTRAB9AL3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7937215 | 0.93 | RAB9A (0.40) | MAPTRAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL18417624 | 0.93 | MAPT (0.37) | MAPTRAB9AL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184415-B1 | ASYMMETRIC HYDROGENATION OF A 2-HALO(ELECTRONEGATIVE)ALKENOIC ACID/SALT (2-HALOACRYLIC ACID OR SALT), USING AN ENANTIOMETRICAL RICHED CATALYST OF 2,2'-BIS(DIARYLPHOSPHINO-PHINO-1,1'-BINAPHTHYL COMPLEX OF RUTHENIUM; HALIDE PROMOTERS | ALBEMARLE CORPORATION | 2001-02-06 | — | — | US | disclosed |