Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28363785 | 0.81 | LMNA (0.54) | SMN1; SMN2LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12238399 | 0.81 | LMNA (0.54) | SMN1; SMN2LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL34469187 | 0.80 | LMNA (0.53) | SMN1; SMN2LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14277131 | 0.80 | LMNA (0.61) | SMN1; SMN2LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL218606 | 0.80 | LMNA (0.61) | SMN1; SMN2LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8237046 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14347688 | 0.80 | LMNA (0.61) | SMN1; SMN2LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6972329 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAPOLBGAAGFER | |
| SCHEMBL30792459 | 0.79 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29412848 | 0.79 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNACYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |