Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 16/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.67 |
| ▸ | CDK2 | P24941 | 16/20 | 0.67 |
| ▸ | DBF4 | Q9UBU7 | 16/20 | 0.67 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.55 |
| ▸ | CDK9 | P50750 | 3/20 | 0.55 |
| ▸ | CDK1 | P06493 | 2/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179323 | 0.83 | CDC7 (0.69) | CDC7CCNE1CDK2DBF4CCNT1 | |
| SCHEMBL1558081 | 0.80 | CDK2 (0.60) | CDC7CCNE1CDK2DBF4CCNT1 | |
| SCHEMBL7955526 | 0.79 | BCL2 (0.59) | CDC7CCNE1CDK2DBF4CCNT1 | |
| SCHEMBL7956178 | 0.78 | CDC7 (1.00) | CDC7CCNE1CDK2DBF4CCNT1 | |
| SCHEMBL12321663 | 0.77 | CDK2 (0.58) | CDC7CCNE1CDK2DBF4CCNT1 | |
| SCHEMBL28326793 | 0.76 | CDC7 (0.57) | CDC7CCNE1CDK2DBF4CCNT1 | |
| SCHEMBL1557178 | 0.75 | CDC7 (0.74) | CDC7CCNE1CDK2DBF4CDK9 | |
| SCHEMBL5618155 | 0.75 | TGFBR1 (0.71) | CDC7CDK2CCNT1CDK9TGFBR1 | |
| SCHEMBL7946423 | 0.75 | CDC7 (1.00) | CDC7CCNE1CDK2DBF4CCNT1 | |
| SCHEMBL12322306 | 0.74 | CDK2 (0.52) | CDC7CCNE1CDK2DBF4CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466170-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2013-06-18 | — | — | US | disclosed |
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | JAK3, AZI2, MYLK2 | CDC7 250/4885CCNE1 187/4885CDK2 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.