Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 12/20 | 0.50 |
| ▸ | AKR1C4 | P17516 | 7/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.50 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.48 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1495662 | 0.91 | AKR1C3 (0.55) | HDAC1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL1495539 | 0.87 | AKR1C3 (0.54) | HDAC1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL2383698 | 0.86 | AKR1C3 (0.53) | HDAC1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL2173876 | 0.85 | P2RX3 (0.50) | HDAC1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL2170971 | 0.84 | P2RX3 (0.67) | HDAC1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL12757591 | 0.83 | AKR1C3 (0.56) | HDAC1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL28814525 | 0.83 | AKR1C3 (0.47) | HDAC1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL1495717 | 0.83 | AKR1C3 (0.50) | HDAC1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL1495365 | 0.83 | AKR1C3 (0.49) | HDAC1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL1495558 | 0.82 | AKR1C3 (0.49) | HDAC1AKR1C3AKR1C4AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010033168-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2010-03-25 | — | — | WO | disclosed |