Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955729 | 0.87 | CSNK1D (0.38) | MKNK1MKNK2CYP11B2CSNK1DCSNK1E | |
| SCHEMBL7955731 | 0.87 | CSNK1D (0.38) | MKNK1MKNK2CYP11B2CSNK1DCSNK1E | |
| SCHEMBL7954909 | 0.84 | MKNK1 (0.41) | MKNK1MKNK2CYP11B2CSNK1DCSNK1E | |
| SCHEMBL895772 | 0.83 | MKNK1 (0.41) | MKNK1MKNK2CYP11B2CSNK1DCSNK1E | |
| SCHEMBL7960330 | 0.83 | MKNK1 (0.40) | MKNK1MKNK2CYP11B2CSNK1DCSNK1E | |
| SCHEMBL7953701 | 0.83 | CYP11B2 (0.42) | MKNK1MKNK2CYP11B2CSNK1DCSNK1E | |
| SCHEMBL7957167 | 0.83 | MKNK1 (0.40) | MKNK1MKNK2CYP11B2CSNK1DCSNK1E | |
| SCHEMBL7954819 | 0.82 | KDM4E (0.42) | MKNK1MKNK2CYP11B2CSNK1DCSNK1E | |
| SCHEMBL7953523 | 0.80 | KMT2A (0.44) | MKNK1MKNK2CYP11B2CSNK1DCSNK1E | |
| SCHEMBL7955168 | 0.80 | CSNK1D (0.39) | MKNK1MKNK2CYP11B2CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |