Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953701 | 0.85 | CYP11B2 (0.42) | KMT2AMEN1MKNK1MKNK2CSNK1D | |
| SCHEMBL7954909 | 0.84 | MKNK1 (0.41) | KMT2AMEN1MKNK1MKNK2CSNK1D | |
| SCHEMBL7957167 | 0.83 | MKNK1 (0.40) | KMT2AMEN1MKNK1MKNK2CSNK1D | |
| SCHEMBL7960330 | 0.83 | MKNK1 (0.40) | KMT2AMEN1MKNK1MKNK2CSNK1D | |
| SCHEMBL895772 | 0.83 | MKNK1 (0.41) | KMT2AMEN1MKNK1MKNK2CSNK1D | |
| SCHEMBL7954819 | 0.82 | KDM4E (0.42) | KMT2AMEN1MKNK1MKNK2CSNK1D | |
| SCHEMBL7955729 | 0.81 | CSNK1D (0.38) | KMT2AMEN1MKNK1MKNK2CSNK1D | |
| SCHEMBL7955731 | 0.81 | CSNK1D (0.38) | KMT2AMEN1MKNK1MKNK2CSNK1D | |
| SCHEMBL7946718 | 0.80 | MKNK1 (0.38) | KMT2AMEN1MKNK1MKNK2CSNK1D | |
| SCHEMBL7955168 | 0.80 | CSNK1D (0.39) | KMT2AMEN1MKNK1MKNK2CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |
| EP-0833635-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | Aventis Pharma S.A. (FR) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997000073-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1997-01-03 | — | — | WO | disclosed |