Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.49 |
| ▸ | CASP2 | P42575 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 3/20 | 0.47 |
| ▸ | CES1 | P23141 | 3/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681566 | 0.81 | FAAH (0.62) | FAAHHSP90AA1DNM1CASP2LPAR1 | |
| SCHEMBL11170358 | 0.74 | FAAH (0.77) | FAAHHSP90AA1DNM1CASP2EPHX2 | |
| SCHEMBL8205915 | 0.74 | FAAH (1.00) | FAAHHSP90AA1DNM1CASP2CES2 | |
| SCHEMBL227920 | 0.74 | FAAH (0.77) | FAAHHSP90AA1DNM1CASP2EPHX2 | |
| SCHEMBL25350370 | 0.74 | FAAH (0.77) | FAAHHSP90AA1DNM1CASP2EPHX2 | |
| SCHEMBL25008200 | 0.74 | FAAH (0.77) | FAAHHSP90AA1DNM1CASP2EPHX2 | |
| SCHEMBL8461970 | 0.74 | FAAH (0.77) | FAAHHSP90AA1DNM1CASP2EPHX2 | |
| N-Ethylpalmitamide SCHEMBL4148137 | 0.74 | FAAH (1.00) | FAAHHSP90AA1DNM1CASP2CES2 | |
| SCHEMBL135555 | 0.74 | FAAH (0.77) | FAAHHSP90AA1DNM1CASP2EPHX2 | |
| SCHEMBL4146733 | 0.74 | FAAH (1.00) | FAAHHSP90AA1DNM1CASP2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6261732-B1 | DEVELOPING ELECTROSTATIC LATENT IMAGES WITH LIQUID DEVELOPERS HAVING A VEHICLE THAT IS IN LIQUID FORM UNDER DEVELOPMENT CONDITIONS AND IN SOLID FORM SUBSEQUENT TO DEVELOPMENT | XEROX CORPORATION | 2001-07-17 | — | — | US | disclosed |
| US-5998081-A | DEVELOPMENT OF ELECTROSTATIC LATENT IMAGES. | XEROX CORPORATION (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0605108-A2 | Development processes | XEROX CORPORATION (US) | 1994-07-06 | — | — | EP | disclosed |