Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.68 |
| ▸ | HRH1 | P35367 | 4/20 | 0.68 |
| ▸ | HRH2 | P25021 | 2/20 | 0.68 |
| ▸ | LTA4H | P09960 | 1/20 | 0.62 |
| ▸ | CHKA | P35790 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KHK | P50053 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18590696 | 0.82 | CHKA (0.67) | HRH3HRH1HRH2CHKACYP2D6 | |
| SCHEMBL16439234 | 0.81 | HRH1 (0.55) | HRH3HRH1HRH2CHKAALDH1A1 | |
| SCHEMBL2784743 | 0.81 | LTA4H (0.70) | HRH3HRH1HRH2LTA4HALDH1A1 | |
| SCHEMBL7954928 | 0.80 | HRH1 (0.61) | HRH3HRH1HRH2LTA4HCHKA | |
| SCHEMBL4671620 | 0.80 | LTA4H (0.64) | HRH3HRH1HRH2LTA4HALDH1A1 | |
| SCHEMBL4997726 | 0.80 | HRH1 (0.51) | HRH3HRH1HRH2LTA4HALDH1A1 | |
| SCHEMBL24177916 | 0.79 | LTA4H (0.68) | HRH3HRH1HRH2LTA4HALDH1A1 | |
| SCHEMBL30047550 | 0.78 | LTA4H (0.63) | HRH3HRH1HRH2LTA4HTSHR | |
| SCHEMBL28112415 | 0.78 | CHKA (0.80) | CHKACYP2D6CYP2C9TSHRSMN1; SMN2 | |
| SCHEMBL30440657 | 0.78 | LTA4H (0.66) | LTA4HALDH1A1TSHRMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |