Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 4/20 | 0.44 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.43 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956560 | 0.90 | KDM4E (0.65) | HRH1HRH3KDM4ETP53CYP19A1 | |
| SCHEMBL7947463 | 0.84 | HRH3 (0.61) | HRH1HRH3KDM4ETP53HRH2 | |
| SCHEMBL7954927 | 0.84 | HRH1 (0.52) | HRH1HRH3KDM4ETP53HRH2 | |
| SCHEMBL12635874 | 0.83 | KDM4E (0.56) | HRH1HRH3KDM4ETP53HRH2 | |
| SCHEMBL12634627 | 0.83 | CHEK1 (0.58) | HRH1HRH3KDM4ETP53ALDH1A1 | |
| SCHEMBL3056827 | 0.81 | CYP19A1 (0.65) | HRH1HRH3KDM4ECYP19A1ALDH1A1 | |
| SCHEMBL12635872 | 0.81 | ALDH1A1 (0.65) | HRH1HRH3KDM4ETP53HRH2 | |
| SCHEMBL7947342 | 0.80 | HRH3 (0.68) | HRH1HRH3HRH2ALDH1A1ADRB2 | |
| SCHEMBL2384959 | 0.79 | KDM4E (0.80) | HRH1HRH3KDM4ETP53ALDH1A1 | |
| SCHEMBL7954966 | 0.79 | KDM4E (0.51) | HRH1HRH3KDM4ETP53CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |