Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846474 | 0.81 | HSD17B10 (0.50) | HSD17B10MAOAMAOBSCN9ASLC6A4 | |
| SCHEMBL6482247 | 0.80 | L3MBTL1 (0.49) | HSD17B10MAOAMAOBSCN9ASLC6A4 | |
| SCHEMBL31468197 | 0.79 | SCN9A (0.53) | HSD17B10MAOAMAOBSCN9ASLC6A4 | |
| SCHEMBL7956847 | 0.79 | APP (0.56) | MAOAMAOBL3MBTL1ALDH1A1TDP1 | |
| SCHEMBL15010146 | 0.79 | SCN9A (0.53) | HSD17B10MAOAMAOBSCN9ASLC6A4 | |
| SCHEMBL19859227 | 0.79 | SCN9A (0.49) | HSD17B10MAOAMAOBSCN9ASLC6A4 | |
| SCHEMBL2887792 | 0.79 | SCN9A (0.52) | HSD17B10MAOAMAOBSCN9ASLC6A4 | |
| SCHEMBL29464960 | 0.79 | SMN1; SMN2 (0.50) | HSD17B10MAOAMAOBSCN9ASLC6A4 | |
| SCHEMBL19970154 | 0.79 | SMN1; SMN2 (0.50) | HSD17B10MAOAMAOBSCN9ASLC6A4 | |
| SCHEMBL20609867 | 0.75 | HSD17B10 (0.47) | HSD17B10L3MBTL1ALDH1A1TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |