Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 11/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387253 | 0.96 | SSTR5 (0.42) | SSTR5HRH1CYP2D6HTR3ATP53 | |
| SCHEMBL8303798 | 0.92 | SSTR5 (0.41) | SSTR5HRH1CYP2D6HTR3ATP53 | |
| SCHEMBL8307210 | 0.88 | SSTR5 (0.41) | SSTR5HRH1CYP2D6HTR3ATP53 | |
| SCHEMBL1388865 | 0.87 | HRH1 (0.52) | HRH1TACR1 | |
| SCHEMBL1387145 | 0.85 | HRH1 (0.53) | SSTR5HRH1TACR2TACR1 | |
| SCHEMBL7954465 | 0.84 | HRH1 (0.49) | SSTR5HRH1TACR1ALDH1A1 | |
| SCHEMBL7961463 | 0.83 | HRH1 (0.51) | SSTR5HRH1CYP2D6HTR3ATP53 | |
| SCHEMBL7962558 | 0.83 | HRH1 (0.50) | SSTR5HRH1TACR1 | |
| SCHEMBL1387148 | 0.82 | HRH1 (0.51) | HRH1TACR1 | |
| SCHEMBL8303800 | 0.82 | SSTR5 (0.38) | SSTR5HRH1CYP2D6HTR3ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329392-B1 | ANTIALLERGENS | AVENTIS PHARMACEUTICALS, INC. | 2001-12-11 | — | — | US | disclosed |
| EP-0777666-B1 | SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMA INC (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0777666-A1 | NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMACEUTICALS INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996006094-A1 | NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMACEUTICALS INC. (US) | 1996-02-29 | — | — | WO | disclosed |