Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 9/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 3/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387253 | 0.91 | SSTR5 (0.42) | SSTR5HTR3AHRH1CYP2D6TP53 | |
| SCHEMBL7947445 | 0.88 | SSTR5 (0.41) | SSTR5HTR3AHRH1CYP2D6TP53 | |
| SCHEMBL8303798 | 0.86 | SSTR5 (0.41) | SSTR5HTR3AHRH1CYP2D6TP53 | |
| SCHEMBL1388865 | 0.82 | HRH1 (0.52) | HRH1TACR1 | |
| SCHEMBL1387145 | 0.81 | HRH1 (0.53) | SSTR5HRH1TACR2TACR1 | |
| SCHEMBL7947451 | 0.80 | SSTR5 (0.44) | SSTR5HTR3AHRH1CYP2D6CHRM1 | |
| SCHEMBL7954465 | 0.80 | HRH1 (0.49) | SSTR5HRH1TACR1 | |
| SCHEMBL7958381 | 0.79 | KMT2A (0.45) | SSTR5HTR3AHRH1CYP2D6CHRM1 | |
| SCHEMBL7961463 | 0.78 | HRH1 (0.51) | SSTR5HTR3AHRH1CYP2D6TP53 | |
| SCHEMBL7962558 | 0.78 | HRH1 (0.50) | SSTR5HRH1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777666-B1 | SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMA INC (US) | 1999-03-03 | — | — | EP | disclosed |