Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958723 | 0.88 | DRD2 (0.55) | PARP1HDAC6HIF1AEPAS1HSD17B10 | |
| SCHEMBL15853639 | 0.87 | HIF1A (0.59) | KCNH2HDAC6HIF1AEPAS1HDAC1 | |
| SCHEMBL7961490 | 0.86 | MAPT (0.54) | HDAC6DRD2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5633970 | 0.85 | CHKA (0.56) | HDAC6HSD17B10KMT2AHDAC1POLB | |
| SCHEMBL5632521 | 0.84 | POLB (0.54) | HDAC6HIF1AEPAS1POLBMAPT | |
| SCHEMBL6135186 | 0.83 | POLB (0.57) | HDAC6HIF1AEPAS1HDAC1DRD2 | |
| SCHEMBL6133671 | 0.80 | MAPT (0.53) | HDAC6HIF1AEPAS1HSD17B10KMT2A | |
| SCHEMBL5987374 | 0.80 | HTR2A (0.59) | HDAC6KMT2AHDAC1DRD2POLB | |
| SCHEMBL10154345 | 0.79 | HDAC6 (0.78) | KCNH2HDAC6HDAC1LMNAHDAC3 | |
| SCHEMBL16810264 | 0.79 | HDAC6 (0.60) | PARP1KCNH2PARP2HDAC6HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |