Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947565 | 0.88 | PARP1 (0.54) | DRD2PARP1HDAC6HIF1AEPAS1 | |
| SCHEMBL5633970 | 0.82 | CHKA (0.56) | HDAC6HDAC1KMT2AHSD17B10 | |
| SCHEMBL5632521 | 0.82 | POLB (0.54) | HDAC6HIF1AEPAS1 | |
| SCHEMBL16809276 | 0.82 | HDAC6 (0.58) | HDAC6HDAC1KMT2AHDAC4HDAC8 | |
| SCHEMBL6135186 | 0.81 | POLB (0.57) | DRD2HDAC6HIF1AEPAS1HDAC1 | |
| SCHEMBL8385135 | 0.80 | HDAC6 (0.74) | HDAC6HDAC1KMT2AHDAC3HDAC4 | |
| SCHEMBL5987374 | 0.80 | HTR2A (0.59) | DRD2HDAC6HDAC1KMT2AHDAC3 | |
| SCHEMBL8251460 | 0.79 | POLB (0.56) | DRD2 | |
| SCHEMBL22106236 | 0.78 | HDAC1 (0.56) | HDAC6HDAC1KMT2AHDAC4HDAC8 | |
| SCHEMBL18811751 | 0.78 | HDAC1 (0.56) | HDAC6HDAC1KMT2AHDAC4HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |