Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.82 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005158 | 0.90 | PDE5A (1.00) | PDE5APDE4BNR3C1 | |
| SCHEMBL7955535 | 0.87 | PDE5A (0.72) | PDE5APDE4BNR3C1 | |
| SCHEMBL7955490 | 0.85 | PDE5A (0.90) | PDE5APDE4BNR3C1 | |
| SCHEMBL7948031 | 0.84 | PDE5A (0.82) | PDE5APDE4BNR3C1GAA | |
| SCHEMBL7954877 | 0.83 | PDE5A (0.87) | PDE5APDE4BNR3C1CDK2GSK3B | |
| SCHEMBL12551683 | 0.83 | PDE5A (0.86) | PDE5APDE4BNR3C1 | |
| SCHEMBL7955209 | 0.82 | PDE5A (0.84) | PDE5APDE4BNR3C1ALDH1A1MAPK1 | |
| SCHEMBL7096587 | 0.81 | PDE5A (0.83) | PDE5APDE4BNR3C1 | |
| SCHEMBL7956986 | 0.81 | PDE5A (0.82) | PDE5APDE4BNR3C1 | |
| SCHEMBL7958851 | 0.80 | PDE5A (0.81) | PDE5APDE4BNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326379-B1 | ERECTILE DYSFUNCTION; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. | 2001-12-04 | — | — | US | disclosed |