SCHEMBL7948102

SCHEMBL7948102

O=C(Oc1ccc2c(=O)cc(-c3ccccc3)oc2c1)c1ccccc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.68
MAPT P10636 3/20 0.68
TP53 P04637 3/20 0.68
SMN1; SMN2 Q16637 3/20 0.68
CYP3A4 P08684 2/20 0.68
MEN1 O00255 1/20 0.68
LMNA P02545 1/20 0.68
CA9 Q16790 4/20 0.67
CYP19A1 P11511 4/20 0.65
TNKS O95271 4/20 0.65
KDM4E B2RXH2 4/20 0.62
ALDH1A1 P00352 2/20 0.62
GAA P10253 2/20 0.62
GLA P06280 1/20 0.62
NPBWR1 P48145 1/20 0.62
PRKDC P78527 1/20 0.61
CA12 O43570 3/20 0.60
MAOB P27338 2/20 0.60
CA1 P00915 2/20 0.60
CA2 P00918 2/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4172232 0.85 MAPT (0.74) KMT2AMAPTTP53SMN1; SMN2CYP3A4
SCHEMBL31499219 0.82 CYP3A4 (0.77) KMT2AMAPTTP53SMN1; SMN2CYP3A4
SCHEMBL27493025 0.81 SMN1; SMN2 (1.00) KMT2AMAPTTP53SMN1; SMN2CYP3A4
SCHEMBL27618931 0.81 SMN1; SMN2 (0.76) KMT2AMAPTTP53SMN1; SMN2CYP3A4
SCHEMBL30540840 0.81 SMN1; SMN2 (1.00) KMT2AMAPTTP53SMN1; SMN2CYP3A4
SCHEMBL13609780 0.81 CYP3A4 (0.67) KMT2AMAPTTP53SMN1; SMN2CYP3A4
SCHEMBL27784284 0.80 CYP19A1 (0.65) KMT2AMAPTTP53SMN1; SMN2CYP3A4
SCHEMBL12941004 0.80 NPSR1 (0.69) KMT2AMAPTTP53SMN1; SMN2CYP3A4
7-Methoxyflavone SCHEMBL1373009 0.79 TNKS (1.00) KMT2AMAPTTP53SMN1; SMN2CYP3A4
SCHEMBL6497044 0.79 TNKS (0.74) KMT2AMAPTTP53SMN1; SMN2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6255497-B1 DAIDZIN DERIVATIVES AS ENZYME INHIBITORS OF ALDEHYDE DEHYDROGENASE; USEFUL IN TREATING ALCOHOLISM THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. 2001-07-03 US disclosed
US-5886028-A REDUCING ALCOHOL CONSUMPTION BY ADMINISTERING AN ENZYME INHIBITOR THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) 1999-03-23 US disclosed
US-5624910-A INHIBITING ALDEHYDE DEHYRDOGENASE ACTIVITY USING DAIDZIN THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) 1997-04-29 US disclosed
EP-0592583-A1 METHOD FOR THE INHIBITION OF ALDH-I USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) 1994-04-20 EP disclosed
US-5204369-A METHOD FOR THE INHIBITION OF ALDH-I USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY (US) 1993-04-20 US disclosed
WO-1993000896-A1 METHOD FOR THE INHIBITION OF ALDH-I USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) 1993-01-21 WO disclosed