SCHEMBL7948196

SCHEMBL7948196

C=CC(=O)OC[Si]1(C)CCC(C)(C)O[Si]1(C)C

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.34
HPGD P15428 1/20 0.33
ALDH1A1 P00352 4/20 0.33
TP53 P04637 3/20 0.33
HIF1A Q16665 3/20 0.33
CYP3A4 P08684 2/20 0.33
HSD17B10 Q99714 1/20 0.33
MAPK1 P28482 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7794932 0.83 HCAR2 (0.40)
SCHEMBL7949985 0.78 TSHR (0.31) TSHR
SCHEMBL6663536 0.76
SCHEMBL9576204 0.73 ATM (0.39)
SCHEMBL11658360 0.73 HPGD (0.30) TSHRHPGD
SCHEMBL3113887 0.70 TSHR (0.33) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL9246674 0.69 THRB (0.35) TSHRALDH1A1
SCHEMBL8356186 0.69 TSHR (0.42) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL7936332 0.69 TSHR (0.40) TSHRALDH1A1
SCHEMBL2441414 0.68 TSHR (0.34) TSHRHPGDALDH1A1TP53HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11866531-B2 Oil-resistant lens material and ophthalmic devices Twenty Twenty Therapeutrics LLC (US) 2024-01-09 US disclosed
WO-2021067189-A1 OIL-RESISTANT LENS MATERIAL AND ELECTROWETTING OPHTHALMIC DEVICES VERILY LIFE SCIENCES LLC (US) 2021-04-08 WO disclosed
US-20210095063-A1 OIL-RESISTANT LENS MATERIAL AND OPHTHALMIC DEVICES VERILY LIFE SCIENCES LLC 2021-04-01 US disclosed
US-10752833-B2 Optical element for correcting color blindness NITTO DENKO CORPORATION (JP) 2020-08-25 US disclosed
CN-105209936-B Optical element for correcting color blindness 日东电工株式会社 2020-01-14 CN disclosed
CN-104024891-B For correcting the optical element of colour blindness 日东电工株式会社 2019-06-28 CN disclosed
US-20190194535-A1 OPTICAL ELEMENT FOR CORRECTING COLOR BLINDNESS NITTO DENKO CORPORATION (JP) 2019-06-27 US disclosed
US-10119070-B2 Optical element for correcting color blindness NITTO DENKO CORPORATION (JP) 2018-11-06 US disclosed
US-9885883-B2 Optical element for correcting color blindness NITTO DENKO CORPORATION (JP) 2018-02-06 US disclosed
US-20170088771-A1 OPTICAL ELEMENT FOR CORRECTING COLOR BLINDNESS NITTO DENKO CORPORATION (JP) 2017-03-30 US disclosed
EP-0434362-A1 Graft copolymer, solution containing the graft copolymer, and method of treating contact lens with the solution Tomei Sangyo Kabushiki Kaisha (JP) 1991-06-26 EP disclosed
EP-0424099-A2 Method of Preparing Polymeric Compositions for Oxygen Permeable Contact Lenses POLYMER TECHNOLOGY CORPORATION (US) 1991-04-24 EP disclosed
US-4996275-A With silicon group-substituted addition polymers; oxygen permeability, hydrophilic, deposit resistance POLYMER TECHNOLOGY CORPORATION (US) 1991-02-26 US disclosed
US-4814402-A VINYLPYRROLIDONE OR METHACRYLIC ACID AND SILICON CONTAINING METHACRYLATE MENICON CO., LTD. (JP) 1989-03-21 US disclosed
EP-0294515-A2 Contact lens material Menicon Co., Ltd. (JP) 1988-12-14 EP disclosed
US-4686267-A Fluorine containing polymeric compositions useful in contact lenses POLYMER TECHNOLOGY CORPORATION (US) 1987-08-11 US disclosed
EP-0219312-A2 Improved fluorine containing polymeric compositions useful in contact lenses POLYMER TECHNOLOGY CORPORATION (US) 1987-04-22 EP disclosed
US-4594401-A Oxygen permeable hard contact lens formed from styrene monomer containing a silyl or siloxane group SHIN-ETSU CHEMICAL CO., LTD. (JP) 1986-06-10 US disclosed
US-4433125-A COPOLYMER OF SILICON CONTAINING ACRYLATE OR METHACRYLATE, AND FLUOROALKYL ACRYLATE OR METHACRYLATE SHIN-ETSU CHEMICAL CO., LTD. (JP) 1984-02-21 US disclosed
US-RE31406-E POLYSILOXANYLALKYL ACRYLATE AND ALKYL ACRYLATE COPOLYMER SYNTEX (U.S.A.) INC. (US) 1983-10-04 US disclosed