Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 2/20 | 0.38 |
| ▸ | EDNRA | P25101 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | AQP1 | P29972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313378 | 0.76 | EDNRA (0.63) | KDM4EMAPTRAB9ANPC1HSD17B10 | |
| SCHEMBL6313203 | 0.63 | EDNRA (0.63) | KDM4EMAPTRAB9ANPC1HSD17B10 | |
| SCHEMBL6313421 | 0.62 | EDNRA (0.66) | KDM4EMAPTRAB9ANPC1HSD17B10 | |
| SCHEMBL30388409 | 0.61 | NPC1 (0.65) | KDM4EMAPTRAB9ANPC1TP53 | |
| SCHEMBL1623124 | 0.58 | NPC1 (0.54) | KDM4EMAPTRAB9ANPC1NFKB1 | |
| SCHEMBL7949184 | 0.57 | EDNRA (0.50) | KDM4EMAPTRAB9ANPC1HSD17B10 | |
| SCHEMBL7946892 | 0.57 | EDNRA (0.49) | KDM4EMAPTRAB9ANPC1HSD17B10 | |
| SCHEMBL6314152 | 0.56 | EDNRA (0.66) | KDM4EMAPTRAB9ANPC1HSD17B10 | |
| SCHEMBL31125166 | 0.56 | MAPT (0.63) | KDM4EMAPTRAB9ANPC1HSD17B10 | |
| SCHEMBL7951239 | 0.56 | EDNRA (0.45) | KDM4EMAPTRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |