Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 11/20 | 0.51 |
| ▸ | EDNRB | P24530 | 10/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9154629 | 0.91 | EDNRA (0.51) | EDNRAEDNRBTSHRMAPTHPGD | |
| SCHEMBL9152826 | 0.90 | EDNRA (0.49) | EDNRAEDNRBTSHRMAPTHPGD | |
| SCHEMBL9152792 | 0.90 | EDNRA (0.54) | EDNRAEDNRBTSHRMAPTHPGD | |
| SCHEMBL9152112 | 0.87 | EDNRA (0.54) | EDNRAEDNRBTSHRMAPTHPGD | |
| SCHEMBL9151761 | 0.87 | ALDH1A1 (0.49) | EDNRATSHRMAPTHPGDMEN1 | |
| SCHEMBL8321783 | 0.86 | EDNRA (0.58) | EDNRAEDNRBTSHRMAPTHPGD | |
| SCHEMBL8324961 | 0.85 | EDNRA (0.58) | EDNRAEDNRBTSHRMAPTHPGD | |
| SCHEMBL8319472 | 0.85 | EDNRA (0.56) | EDNRAEDNRBTSHRMAPTHPGD | |
| SCHEMBL8327799 | 0.84 | EDNRA (0.57) | EDNRAEDNRBTSHRMAPTHPGD | |
| SCHEMBL8326435 | 0.83 | EDNRA (0.45) | EDNRAEDNRBTSHRMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | claimed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| US-5420129-A | Treatment of hypertension, ischemia, vasospasms, angina | HOFFMANN-LA ROCHE INC. (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |