SCHEMBL7948355

SCHEMBL7948355

[CH2]CCCCCOCC(c1ccccc1)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.37
CA1 P00915 2/20 0.37
CA2 P00918 2/20 0.37
CA9 Q16790 2/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
C3AR1 Q16581 2/20 0.35
GRIN1 Q05586 2/20 0.35
GRIN2A Q12879 2/20 0.35
HTR2A P28223 3/20 0.34
KCNA3 P22001 1/20 0.34
TAAR1 Q96RJ0 1/20 0.34
HRH1 P35367 3/20 0.34
CA7 P43166 1/20 0.33
HDAC3 O15379 1/20 0.32
HDAC4 P56524 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC7 Q8WUI4 1/20 0.32
HDAC2 Q92769 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7963027 0.92 CA12 (0.39) CA12CA1CA2CA9C3AR1
SCHEMBL9098680 0.77 AOC3 (0.33) SMN1; SMN2
SCHEMBL27812911 0.77 LTA4H (0.46) CA12CA1CA2CA9SMN1; SMN2
SCHEMBL7959905 0.76 CA12 (0.44) CA12CA1CA2CA9SMN1; SMN2
SCHEMBL7958769 0.76 SLC6A2 (0.50) SMN1; SMN2HTR2AHRH1
SCHEMBL7962993 0.76 SLC6A2 (0.50) SMN1; SMN2HTR2AHRH1
SCHEMBL7129055 0.75 HTR2A (0.50) CA12CA1CA2CA9HTR2A
SCHEMBL21995061 0.75 SCN4A (0.57) TACR1SCN4A
SCHEMBL21995022 0.75 SCN4A (0.57) TACR1SCN4A
SCHEMBL22052007 0.75 SCN4A (0.57) TACR1SCN4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6323235-B1 CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS OHTAKE ATSUSHI (JP) 2001-11-27 US disclosed
US-6043264-A A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA TORAY INDUSTRIES, INC. (JP) 2000-03-28 US disclosed
EP-0751126-A1 BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME TORAY INDUSTRIES, INC. (JP) 1997-01-02 EP disclosed