SCHEMBL7959905

SCHEMBL7959905

[CH2]COCC(c1ccccc1)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.44
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
CA9 Q16790 2/20 0.44
HTR2A P28223 5/20 0.42
TAAR1 Q96RJ0 1/20 0.42
HRH1 P35367 5/20 0.39
CA7 P43166 1/20 0.38
SCN4A P35499 2/20 0.38
TACR1 P25103 2/20 0.37
C3AR1 Q16581 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
CHRNB2 P17787 1/20 0.35
CHRNA4 P43681 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
PKM P14618 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
SIGMAR1 Q99720 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7129055 0.85 HTR2A (0.50) CA12CA1CA2CA9HTR2A
SCHEMBL10682089 0.80 LMNA (0.48) CYP1A2SMN1; SMN2
SCHEMBL7963027 0.79 CA12 (0.39) CA12CA1CA2CA9HTR2A
SCHEMBL3317802 0.76 CA12 (0.44) CA12CA1CA2CA9HTR2A
SCHEMBL7948355 0.76 CA12 (0.37) CA12CA1CA2CA9HTR2A
SCHEMBL3809923 0.73 CA12 (0.41) CA12CA1CA2CA9HTR2A
SCHEMBL7956378 0.73 HSD17B10 (0.41) CA12CA1CA2CA9HTR2A
SCHEMBL7651276 0.73 NPC1 (0.49) CA12CA1CA2CA9C3AR1
SCHEMBL11247546 0.72 HTT (0.35) HTR2AHRH1CYP1A2CYP2D6SMN1; SMN2
SCHEMBL4630986 0.72 POLB (0.38) CA2CYP1A2CYP2D6PKMSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6323235-B1 CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS OHTAKE ATSUSHI (JP) 2001-11-27 US disclosed
US-6043264-A A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA TORAY INDUSTRIES, INC. (JP) 2000-03-28 US disclosed
EP-0751126-A1 BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME TORAY INDUSTRIES, INC. (JP) 1997-01-02 EP disclosed