Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.67 |
| ▸ | MAOB | P27338 | 3/20 | 0.63 |
| ▸ | AR | P10275 | 1/20 | 0.63 |
| ▸ | HNF4A | P41235 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | BCHE | P06276 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL127853 | 0.80 | GUSB (1.00) | GUSBMAOBARMAPTBCHE | |
| SCHEMBL1373434 | 0.80 | GUSB (1.00) | GUSBMAOBARMAPTBCHE | |
| SCHEMBL5450210 | 0.79 | GUSB (0.74) | GUSBMAOBARMAPTBCHE | |
| SCHEMBL5450213 | 0.79 | GUSB (0.74) | GUSBMAOBARMAPTBCHE | |
| SCHEMBL20608561 | 0.79 | CYP1B1 (0.70) | MAOBMAPTBCHEMEN1ALDH1A1 | |
| SCHEMBL5446640 | 0.78 | HNF4A (1.00) | HNF4AALDH1A1KLKB1CTSBMMP9 | |
| SCHEMBL27396608 | 0.78 | HNF4A (1.00) | HNF4AALDH1A1KLKB1CTSBMMP9 | |
| SCHEMBL10830021 | 0.78 | AR (1.00) | GUSBMAOBARMAPTBCHE | |
| SCHEMBL6289490 | 0.78 | GUSB (0.72) | GUSBMAOBARHNF4AMAPT | |
| SCHEMBL6289491 | 0.78 | GUSB (0.72) | GUSBMAOBARHNF4AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010021680-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-02-25 | — | — | WO | disclosed |