Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 6/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 4/20 | 0.37 |
| ▸ | MAOA | P21397 | 4/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5695479 | 0.81 | CA2 (0.41) | CA2HTR1ASIGMAR1ADRA2BADRA2C | |
| SCHEMBL29644533 | 0.81 | CA2 (0.41) | CA2HTR1ASIGMAR1ADRA2BADRA2C | |
| SCHEMBL4289906 | 0.81 | CA2 (0.41) | CA2HTR1ASIGMAR1ADRA2BADRA2C | |
| SCHEMBL95677 | 0.81 | CA2 (0.44) | CA2HTR1ASIGMAR1ADRA2BADRA2C | |
| SCHEMBL5130635 | 0.81 | MAOB (0.38) | MAOAMAOBNISCH | |
| SCHEMBL460126 | 0.75 | CA2 (0.44) | CA2HTR1ASIGMAR1ADRA2BADRA2C | |
| SCHEMBL30070640 | 0.75 | CA2 (0.44) | CA2HTR1ASIGMAR1ADRA2BADRA2C | |
| SCHEMBL1567113 | 0.75 | HTR1A (0.45) | CA2HTR1ASIGMAR1ADRA2BADRA2C | |
| SCHEMBL29462397 | 0.74 | CA2 (0.46) | CA2HTR1ASIGMAR1ADRA2BADRA2C | |
| SCHEMBL9006852 | 0.74 | ESR1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258811-B1 | ADMINISTERING RETINOIC ACID RECEPTOR AGONIST | EISAI CO., LTD. (JP) | 2001-07-10 | — | — | US | claimed |
| US-6258811-B1 | ADMINISTERING RETINOIC ACID RECEPTOR AGONIST | EISAI CO., LTD. (JP) | 2001-07-10 | — | — | US | disclosed |
| EP-0930075-A1 | METHODS FOR PREVENTING, INHIBITING OR TREATING GRAFT REJECTION REACTIONS IN GRAFT-VERSUS-HOST DISEASE (GVHD) AND ORGAN TRANSPLANTATION | Eisai Co., Ltd. (JP) | 1999-07-21 | — | — | EP | disclosed |
| EP-0320777-B1 | A NOVEL APPROACH TO PRODUCE NATURAL VITAMIN E MAKING USE OF AN ASYMMETRIC SYNTHESIS | F. HOFFMANN-LA ROCHE AG (CH) | 1992-03-18 | — | — | EP | disclosed |
| EP-0290130-B1 | ACETYLENES DISUBSTITUTED WITH A PHENYL GROUP AND A HETEROBICYCLIC GROUP HAVING RETINOID LIKE ACTIVITY | ALLERGAN, INC (US) | 1991-11-06 | — | — | EP | disclosed |
| EP-0320777-A2 | A novel approach to produce natural vitamin E making use of an asymmetric synthesis | F. HOFFMANN-LA ROCHE AG (CH) | 1989-06-21 | — | — | EP | disclosed |
| US-4810804-A | PSORIASIS | ALLERGAN, INC. (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0290130-A1 | Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid like activity | ALLERGAN, INC (US) | 1988-11-09 | — | — | EP | disclosed |