SCHEMBL7948851

SCHEMBL7948851

Cc1ccc(S(=O)(=O)NCCn2ccc3c(OCC(=O)O)cccc32)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP24A1 Q07973 5/20 0.53
MCL1 Q07820 1/20 0.52
ALDH1A1 P00352 2/20 0.47
MEN1 O00255 1/20 0.47
USP2 O75604 1/20 0.47
ESR1 P03372 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CASP1 P29466 1/20 0.47
CYP2C19 P33261 1/20 0.47
KMT2A Q03164 1/20 0.47
PSEN1 P49768 1/20 0.42
PSEN2 P49810 1/20 0.42
APH1B Q8WW43 1/20 0.42
NCSTN Q92542 1/20 0.42
APH1A Q96BI3 1/20 0.42
PSENEN Q9NZ42 1/20 0.42
PPARG P37231 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7958504 0.92 ALDH1A1 (0.57) CYP24A1MCL1ALDH1A1PPARGPPARA
SCHEMBL7957937 0.81 MCL1 (0.50) MCL1ALDH1A1PPARGPPARAMAPT
SCHEMBL7956866 0.78 MCL1 (0.48) MCL1ALDH1A1PPARGPPARA
SCHEMBL7959506 0.75 MCL1 (0.60) MCL1ALDH1A1MEN1KMT2APPARG
SCHEMBL7960155 0.74 MCL1 (0.59) MCL1ALDH1A1MEN1KMT2APPARG
SCHEMBL9836262 0.74 TBXA2R (0.55) ALDH1A1MEN1USP2KMT2AMAPT
SCHEMBL7956741 0.74 MCL1 (0.52) MCL1ALDH1A1MEN1USP2KMT2A
SCHEMBL10373954 0.73 ALDH1A1 (0.80) CYP24A1ALDH1A1MEN1USP2ESR1
SCHEMBL10374719 0.71 KCNA5 (0.58) CYP24A1MCL1ALDH1A1MEN1USP2
SCHEMBL10202539 0.71 MEN1 (0.55) MCL1ALDH1A1MEN1KMT2APPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6323235-B1 CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS OHTAKE ATSUSHI (JP) 2001-11-27 US disclosed
US-6043264-A A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA TORAY INDUSTRIES, INC. (JP) 2000-03-28 US disclosed
EP-0751126-A1 BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME TORAY INDUSTRIES, INC. (JP) 1997-01-02 EP disclosed