Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.46 |
| ▸ | RXRB | P28702 | 9/20 | 0.44 |
| ▸ | RXRG | P48443 | 6/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956351 | 0.78 | HRH3 (0.50) | RXRARXRBRXRGCYP2D6 | |
| SCHEMBL7963222 | 0.72 | MEN1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL3372724 | 0.71 | RXRB (0.72) | RXRARXRBRXRGMRGPRX4S1PR5 | |
| SCHEMBL7959109 | 0.69 | TP53 (0.53) | MRGPRX4 | |
| SCHEMBL27695081 | 0.69 | RXRA (0.53) | RXRARXRBRXRGMRGPRX4S1PR5 | |
| SCHEMBL7396044 | 0.69 | RXRA (0.52) | RXRARXRBRXRGMRGPRX4ADRA2A | |
| SCHEMBL14367888 | 0.69 | NPC1 (0.48) | — | |
| SCHEMBL9719997 | 0.69 | RXRA (0.55) | RXRARXRBRXRGMRGPRX4ADRA2A | |
| SCHEMBL16397981 | 0.68 | RXRB (0.72) | RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL13180577 | 0.68 | NPC1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245761-B1 | NERVOUS SYSTEM, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY | 2001-06-12 | — | — | US | claimed |
| US-6245761-B1 | NERVOUS SYSTEM, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY | 2001-06-12 | — | — | US | disclosed |