Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR2B | P41595 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 4/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807593 | 0.80 | FAAH (0.57) | FAAHHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL7948957 | 0.72 | RXRA (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL12073902 | 0.71 | HTR1A (0.60) | MEN1KMT2AHTR1AHTR2BDRD2 | |
| SCHEMBL3161038 | 0.70 | MEN1 (0.82) | MEN1KMT2ADRD2HRH1DRD4 | |
| SCHEMBL7959109 | 0.69 | TP53 (0.53) | HTR1ADRD2NPY1RMAPT | |
| SCHEMBL14367888 | 0.68 | NPC1 (0.48) | KMT2A | |
| SCHEMBL13284339 | 0.68 | MEN1 (0.79) | MEN1KMT2AHTR1AHTR2BDRD2 | |
| SCHEMBL1143420 | 0.68 | MAPT (0.68) | MEN1KMT2AHTR1AHTR2BDRD2 | |
| SCHEMBL4818709 | 0.68 | KDM4E (0.58) | KMT2AHTR1ADRD2HRH1DRD4 | |
| SCHEMBL10103770 | 0.67 | IDH1 (0.48) | KCNH2HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245761-B1 | NERVOUS SYSTEM, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY | 2001-06-12 | — | — | US | claimed |
| US-6245761-B1 | NERVOUS SYSTEM, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY | 2001-06-12 | — | — | US | disclosed |