Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2219429 | 0.78 | PTGS1 (0.59) | KDM4EALDH1A1HPGDPTGS1PTGS2 | |
| SCHEMBL7949517 | 0.77 | ALDH1A1 (0.45) | KDM4EMAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL12514946 | 0.77 | KDM4E (0.41) | KDM4EMAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL7942161 | 0.75 | KMT2A (0.49) | KDM4EMAPTALDH1A1PTGS1PTGS2 | |
| SCHEMBL3235534 | 0.75 | ENPP2 (0.55) | KDM4EMAPTNPSR1ALDH1A1ADORA3 | |
| SCHEMBL28570789 | 0.72 | HSP90AA1 (0.47) | KDM4EMAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL3083984 | 0.71 | ALDH1A1 (0.42) | KDM4EMAPTNPSR1ALDH1A1PTGS1 | |
| SCHEMBL13456146 | 0.71 | KDM4E (0.47) | KDM4EMAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL22519132 | 0.71 | KDM4E (0.55) | KDM4EMAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL9925517 | 0.71 | KDM4E (0.47) | KDM4EMAPTNPSR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009154300-A2 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-23 | — | — | WO | disclosed |