Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956285 | 0.76 | RXFP1 (0.56) | ACHEGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL2652555 | 0.73 | GABRG2 (0.78) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10923158 | 0.70 | RXFP1 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1204356 | 0.67 | — | — | |
| Bromide SCHEMBL1204101 | 0.66 | — | — | |
| SCHEMBL10204237 | 0.64 | — | — | |
| SCHEMBL10968183 | 0.64 | GLA (0.33) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2647054 | 0.63 | SMN1; SMN2 (0.43) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Bromide SCHEMBL1205152 | 0.63 | — | — | |
| SCHEMBL2878082 | 0.62 | HSD11B1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255305-B1 | PSYCHOLOGICAL DISORDERS | MERCK SHARP & DOHME LIMITED (GB) | 2001-07-03 | — | — | US | disclosed |