Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 17/20 | 0.61 |
| ▸ | GABRB3 | P28472 | 17/20 | 0.61 |
| ▸ | GABRA3 | P34903 | 17/20 | 0.61 |
| ▸ | GABRA1 | P14867 | 16/20 | 0.61 |
| ▸ | GABRA2 | P47869 | 15/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 11/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL339241 | 0.89 | GABRG2 (0.64) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341741 | 0.79 | GABRG2 (0.62) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL340896 | 0.77 | GABRA1 (0.78) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341650 | 0.76 | GABRG2 (0.67) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL342027 | 0.76 | GABRA1 (0.69) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL340744 | 0.76 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341851 | 0.76 | GABRA1 (0.69) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6040307 | 0.75 | GABRA1 (0.68) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341055 | 0.75 | GABRA1 (0.63) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341709 | 0.75 | GABRA1 (0.62) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255305-B1 | PSYCHOLOGICAL DISORDERS | MERCK SHARP & DOHME LIMITED (GB) | 2001-07-03 | — | — | US | claimed |