Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.57 |
| ▸ | CCR4 | P51679 | 16/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7939786 | 0.90 | EDNRA (0.58) | EDNRACCR4PPARGPPARA | |
| SCHEMBL1387247 | 0.86 | EDNRA (0.76) | EDNRACCR4 | |
| SCHEMBL1387204 | 0.81 | EDNRA (0.79) | EDNRACCR4 | |
| SCHEMBL7361198 | 0.78 | ABCB11 (0.69) | EDNRACCR4 | |
| SCHEMBL1387249 | 0.76 | EDNRA (0.66) | EDNRACCR4 | |
| SCHEMBL7946070 | 0.75 | EDNRA (0.60) | EDNRACCR4 | |
| SCHEMBL795555 | 0.75 | EDNRA (0.66) | EDNRACCR4 | |
| SCHEMBL1731821 | 0.75 | CCR4 (0.82) | EDNRACCR4 | |
| SCHEMBL1387336 | 0.75 | CCR4 (0.66) | EDNRACCR4 | |
| SCHEMBL1387374 | 0.75 | EDNRA (0.85) | EDNRACCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| US-5668137-A | N-heterocyclic sulfonamides having endothelin receptor activity | ZENECA LTD. (GB) | 1997-09-16 | — | — | US | disclosed |