Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 3/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 5/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228556 | 0.86 | EPHX2 (0.40) | EPHX2HDAC6POLQKIF11NOTUM | |
| SCHEMBL2679255 | 0.85 | HDAC6 (0.39) | EPHX2HDAC6POLQDDR1NOTUM | |
| SCHEMBL6293963 | 0.84 | ALDH1A1 (0.46) | EPHX2 | |
| SCHEMBL13617388 | 0.83 | MAOB (0.46) | EPHX2HDAC6MAOB | |
| SCHEMBL16951384 | 0.82 | EPHX2 (0.41) | EPHX2HDAC6POLQPPARGKIF11 | |
| SCHEMBL27927540 | 0.82 | PTPN1 (0.40) | EPHX2HDAC6POLQDDR1NOTUM | |
| SCHEMBL23967939 | 0.81 | KIF11 (0.41) | EPHX2HDAC6POLQPPARGKIF11 | |
| SCHEMBL3902837 | 0.80 | NOTUM (0.60) | EPHX2NOTUM | |
| SCHEMBL2680326 | 0.80 | NOTUM (0.42) | HDAC6KIF11NOTUM | |
| SCHEMBL31542017 | 0.80 | NOTUM (0.42) | HDAC6KIF11NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | disclosed |
| EP-0986559-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998054184-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-03 | — | — | WO | disclosed |