Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.45 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.44 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953963 | 0.88 | KMT2A (0.56) | TP53LMNAMAPTALDH1A1HSD17B10 | |
| SCHEMBL7958661 | 0.87 | KDR (0.47) | TP53LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7951767 | 0.85 | MAPT (0.47) | LMNAMAPTHSD17B10KMT2AALOX15 | |
| SCHEMBL7953382 | 0.85 | ROCK2 (0.53) | MAPTALDH1A1HSD17B10KMT2AUSP2 | |
| SCHEMBL7945185 | 0.85 | RAB9A (0.49) | TP53SMN1; SMN2KDM4ERAB9ANPC1 | |
| SCHEMBL7953966 | 0.84 | TRPV1 (0.51) | TP53LMNAMAPTALDH1A1HSD17B10 | |
| SCHEMBL6293747 | 0.84 | TP53 (0.61) | TP53LMNAMAPTALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL8126991 | 0.84 | RAB9A (0.48) | TP53SMN1; SMN2KDM4ERAB9ANPC1 | |
| SCHEMBL7955681 | 0.83 | MEN1 (0.46) | TP53KMT2ASMN1; SMN2KDM4ERAB9A | |
| SCHEMBL7953316 | 0.83 | PDGFRB (0.47) | LMNAMAPTKMT2AUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | claimed |
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | disclosed |