Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16414613 | 0.86 | TSHR (0.60) | SCN1ASCN5ASCN9AKDM4EPRMT5 | |
| SCHEMBL16414719 | 0.86 | TSHR (0.60) | SCN1ASCN5ASCN9AKDM4EPRMT5 | |
| SCHEMBL817445 | 0.86 | TSHR (0.60) | SCN1ASCN5ASCN9AKDM4EPRMT5 | |
| SCHEMBL4047162 | 0.86 | L3MBTL1 (0.54) | KDM4EPRMT5WDR77MAOBAOC3 | |
| SCHEMBL5575173 | 0.85 | KDM4E (0.49) | SCN1ASCN5ASCN9AKDM4EPRMT5 | |
| SCHEMBL773252 | 0.85 | MAOB (0.55) | SCN1ASCN5ASCN9AKDM4EPRMT5 | |
| SCHEMBL11613592 | 0.85 | KDM4E (0.49) | SCN1ASCN5ASCN9AKDM4EPRMT5 | |
| SCHEMBL7774040 | 0.82 | L3MBTL1 (0.50) | KDM4EPRMT5WDR77MAOBAOC3 | |
| SCHEMBL10485700 | 0.82 | KDM4E (0.47) | SCN1ASCN5ASCN9AKDM4EPRMT5 | |
| SCHEMBL4046553 | 0.81 | KDM4E (0.56) | KDM4EMAOBAOC3MRGPRX4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172109-B1 | SIDE EFFECT REDUCTION; ADMINISTERING TOPICALLY | ALCON LABORATORIES, INC. | 2001-01-09 | — | — | US | disclosed |
| EP-0968183-A2 | 13-THIA PROSTAGLANDINS FOR USE IN GLAUCOMA THERAPY | ALCON LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998039293-A2 | 13-THIA PROSTAGLANDINS FOR USE IN GLAUCOMA THERAPY | ALCON LABORATORIES, INC. (US) | 1998-09-11 | — | — | WO | disclosed |