Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | IDH2 | P48735 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16414719 | 1.00 | TSHR (0.60) | TSHRMAPK1KDM4EPRMT5WDR77 | |
| SCHEMBL16414613 | 1.00 | TSHR (0.60) | TSHRMAPK1KDM4EPRMT5WDR77 | |
| SCHEMBL4047162 | 0.88 | L3MBTL1 (0.54) | TSHRMAPK1KDM4EPRMT5WDR77 | |
| SCHEMBL5575173 | 0.86 | KDM4E (0.49) | TSHRMAPK1KDM4EPRMT5WDR77 | |
| SCHEMBL7952233 | 0.86 | SCN1A (0.50) | TSHRMAPK1KDM4EPRMT5WDR77 | |
| SCHEMBL11613592 | 0.86 | KDM4E (0.49) | TSHRMAPK1KDM4EPRMT5WDR77 | |
| SCHEMBL773252 | 0.86 | MAOB (0.55) | KDM4EPRMT5WDR77MAOBAOC3 | |
| SCHEMBL24015832 | 0.85 | KDM4E (0.46) | TSHRMAPK1KDM4EPRMT5WDR77 | |
| SCHEMBL13761630 | 0.84 | TSHR (0.65) | TSHRMAPK1KDM4EL3MBTL1HIF1A | |
| SCHEMBL13155078 | 0.84 | TSHR (0.65) | TSHRMAPK1KDM4EL3MBTL1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031898-A1 | PROCESS FOR PREPARATION OF PROSTAGLANDIN F2 ALPHA ANALOGUES | INSTYTUT FARMACEUTYCZNY (PL) | 2015-01-29 | — | — | US | disclosed |
| EP-2274266-B1 | PROCESS FOR THE PREPARATION OF PROSTAGLANDIN ANALOGUES AND INTERMEDIATES THEREOF | SCINOPHARM TAIWAN LTD (TW) | 2014-10-15 | — | — | EP | disclosed |
| US-8742143-B2 | Process for the preparation of prostaglandin analogues | SCINOPHARM TAIWAN, LTD. (TW) | 2014-06-03 | — | — | US | disclosed |
| US-8742143-B2 | Process for the preparation of prostaglandin analogues | SCINOPHARM TAIWAN, LTD. (TW) | 2014-06-03 | — | — | US | disclosed |
| US-20130211128-A1 | Process for the Preparation of Prostaglandin Analogues | SCINOPHARM TAIWAN LTD. (TW) | 2013-08-15 | — | — | US | disclosed |
| US-20130211128-A1 | Process for the Preparation of Prostaglandin Analogues | SCINOPHARM TAIWAN LTD. (TW) | 2013-08-15 | — | — | US | disclosed |
| US-8436194-B2 | Process for the preparation of prostaglandin analogues and intermediates thereof | SCINOPHARM TAIWAN, LTD. (TW) | 2013-05-07 | — | — | US | disclosed |
| US-20110130577-A1 | Process for the Preparation of Prostaglandin Analogues and Intermediates Thereof | SCINOPHARM TAIWAN LTD. | 2011-06-02 | — | — | US | disclosed |
| US-20110130577-A1 | Process for the Preparation of Prostaglandin Analogues and Intermediates Thereof | SCINOPHARM TAIWAN LTD. | 2011-06-02 | — | — | US | disclosed |
| US-7897795-B2 | Process for the preparation of prostaglandin analogues and intermediates thereof | SCINOPHARM TAIWAN LTD. (TW) | 2011-03-01 | — | — | US | disclosed |
| US-7897795-B2 | Process for the preparation of prostaglandin analogues and intermediates thereof | SCINOPHARM TAIWAN LTD. (TW) | 2011-03-01 | — | — | US | disclosed |
| WO-2009141718-A2 | PROCESS FOR THE PREPARATION OF PROSTAGLANDIN ANALOGUES AND INTERMEDIATES THEREOF | SCINOPHARM TAIWAN LTD. (TW) | 2009-11-26 | — | — | WO | disclosed |
| US-20090259058-A1 | Process for the Preparation of Prostaglandin Analogues and Intermediates Thereof | SCINOPHARM TAIWAN LTD. | 2009-10-15 | — | — | US | disclosed |
| US-20090259058-A1 | Process for the Preparation of Prostaglandin Analogues and Intermediates Thereof | SCINOPHARM TAIWAN LTD. | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090259058-A1 | Process for the Preparation of Prostaglandin Analogues and Intermediates Thereof | PTGIS, PTGES, PTGER1 | TSHR 1742/4885MAPK1 1318/4885KDM4E 4422/4885 |
| US-20150031898-A1 | PROCESS FOR PREPARATION OF PROSTAGLANDIN F2 ALPHA ANALOGUES | PTGES, PTGIS, PTGES2 | TSHR 2046/4885MAPK1 2140/4885KDM4E 2909/4885 |
| US-20110130577-A1 | Process for the Preparation of Prostaglandin Analogues and Intermediates Thereof | PTGIS, PTGES, PTGER1 | TSHR 1742/4885MAPK1 1318/4885KDM4E 4422/4885 |
| US-20130211128-A1 | Process for the Preparation of Prostaglandin Analogues | PTGIS, PTGES, PTGER1 | TSHR 883/4885MAPK1 2014/4885KDM4E 3794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.