Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.33 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 7/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952777 | 0.89 | IDO1 (0.35) | IDO1HSP90AA1HSP90B1TDP2RORC | |
| SCHEMBL7967150 | 0.89 | POLB (0.33) | POLBNSD2DHODH | |
| SCHEMBL8326689 | 0.88 | DHODH (0.36) | IDO1POLBRORCDHODH | |
| SCHEMBL7953686 | 0.87 | POLB (0.31) | POLBDHODH | |
| SCHEMBL7965862 | 0.87 | IDO1 (0.35) | IDO1POLBHSP90AA1HSP90B1KDM4E | |
| SCHEMBL7963830 | 0.86 | DHODH (0.36) | IDO1POLBHSP90AA1KDM4ETDP2 | |
| SCHEMBL7961242 | 0.85 | IDO1 (0.34) | IDO1POLBHSP90AA1KDM4ETDP2 | |
| SCHEMBL7952832 | 0.83 | HCRTR1 (0.34) | IDO1HSP90AA1HSP90B1KDM4ETDP2 | |
| SCHEMBL7965769 | 0.80 | CFTR (0.41) | KDM4E | |
| SCHEMBL7967474 | 0.79 | HSP90AA1 (0.35) | IDO1HSP90AA1HSP90B1TDP2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |