Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953251 | 1.00 | ALOX15 (0.43) | ALOX15ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL238243 | 0.82 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1TSHRLMNAHSD17B10 | |
| SCHEMBL4525123 | 0.82 | ALDH1A1 (0.44) | ALOX15ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL238242 | 0.82 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1TSHRLMNAHSD17B10 | |
| SCHEMBL601377 | 0.82 | ALDH1A1 (0.44) | ALOX15ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL238244 | 0.82 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1TSHRLMNAHSD17B10 | |
| SCHEMBL601376 | 0.82 | ALDH1A1 (0.44) | ALOX15ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL3865587 | 0.80 | ALOX15 (0.38) | ALOX15ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL3865591 | 0.80 | ALOX15 (0.38) | ALOX15ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL3865590 | 0.80 | ALOX15 (0.38) | ALOX15ALDH1A1L3MBTL1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218397-B1 | FOR THERAPY OF STRESS-RELATED ILLNESSES, SUCH AS STRESS-INDUCED DEPRESSION, ANXIETY, AND HEADACHE; ABDOMINAL BOWEL SYNDROME; INFLAMMATORY DISEASES; IMMUNE SUPPRESSION; ALZHEIMER'S DISEASE; GASTRONINTESTINAL DISEASES | PFIZER INC | 2001-04-17 | — | — | US | disclosed |
| EP-0674642-B1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-0674642-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994024095-A1 | IMMUNOSUPPRESSIVE AGENTS | ABBOTT LABORATORIES (US) | 1994-10-27 | — | — | WO | disclosed |
| WO-1994013677-A1 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |