Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 12/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951767 | 0.87 | MAPT (0.47) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| SCHEMBL7951869 | 0.86 | EGFR (0.44) | MAPTSMN1; SMN2HSP90AA1ROCK2KDR | |
| SCHEMBL7958537 | 0.85 | MAPT (0.45) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| SCHEMBL6293953 | 0.85 | ROCK2 (0.55) | ROCK2ROCK1 | |
| SCHEMBL7958661 | 0.85 | KDR (0.47) | MAPTSMN1; SMN2ROCK2KDRROCK1 | |
| SCHEMBL7951760 | 0.85 | MAPT (0.61) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| SCHEMBL7955615 | 0.84 | HTR1D (0.40) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8140883 | 0.84 | MAPT (0.44) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| SCHEMBL7953978 | 0.84 | KMT2A (0.53) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6294000 | 0.84 | ROCK2 (0.54) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | claimed |
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | disclosed |