Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 4/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7958472 | 0.90 | ROCK2 (0.42) | EGFRBRAFDDR1NTRK1ROCK2 | |
| SCHEMBL7955614 | 0.87 | BRAF (0.44) | BRAFSMN1; SMN2KCNQ3KCNQ2ROCK2 | |
| SCHEMBL7953516 | 0.87 | SMN1; SMN2 (0.44) | EGFRBRAFSMN1; SMN2WNT3AABL1 | |
| SCHEMBL7945228 | 0.86 | ABL1 (0.48) | EGFRBRAFABL1BCR | |
| SCHEMBL7953309 | 0.86 | MAPT (0.42) | SMN1; SMN2KDRHSP90AA1ROCK2MAPT | |
| SCHEMBL7945155 | 0.85 | BRAF (0.51) | BRAFROCK2 | |
| Hydrochloric Acid SCHEMBL6295059 | 0.85 | ROCK2 (0.51) | EGFRBRAFROCK2 | |
| SCHEMBL7958661 | 0.82 | KDR (0.47) | SMN1; SMN2KDRROCK2MAPT | |
| SCHEMBL7945192 | 0.82 | HTR2A (0.42) | BRAFSMN1; SMN2WNT3AROCK2TAAR1 | |
| Hydrochloric Acid SCHEMBL8130753 | 0.81 | HTR2A (0.42) | BRAFSMN1; SMN2WNT3AROCK2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | claimed |
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | disclosed |
| EP-0986559-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998054184-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-03 | — | — | WO | disclosed |