Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196130 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2ADRA1AADORA3CACNA1DCACNA1F | |
| SCHEMBL6196437 | 0.82 | POLB (0.35) | SMN1; SMN2ADRA1AALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL8337661 | 0.75 | ADRA1A (0.36) | ADRA1AADORA3CACNA1DCACNA1FCACNA1S | |
| SCHEMBL6197215 | 0.75 | ADRA1A (0.36) | ADRA1AADORA3CACNA1DCACNA1FCACNA1S | |
| SCHEMBL6200738 | 0.75 | ADRA1A (0.35) | SMN1; SMN2ADRA1AADORA3CACNA1DCACNA1F | |
| SCHEMBL6197708 | 0.74 | ADRA1A (0.38) | ADRA1ACYP3A4CYP2C9HTTADRA1D | |
| SCHEMBL6196597 | 0.71 | ADORA3 (0.48) | SMN1; SMN2ADORA3GUSBALDH1A1HTT | |
| SCHEMBL7239516 | 0.71 | CACNA1B (0.49) | ADRA1AADORA3CACNA1DCACNA1FCACNA1S | |
| SCHEMBL6217186 | 0.70 | ADRA1A (0.37) | SMN1; SMN2ADRA1AADORA3CACNA1DCACNA1F | |
| SCHEMBL6782795 | 0.70 | ADRA1A (0.36) | SMN1; SMN2ADRA1AADORA3CACNA1DCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268369-B1 | ALPHA SUB 1 INHIBITORS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-07-31 | — | — | US | disclosed |