Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDFT1 | P37268 | 3/20 | 0.43 |
| ▸ | MMP12 | P39900 | 4/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | TLL1 | O43897 | 1/20 | 0.39 |
| ▸ | BMP1 | P13497 | 1/20 | 0.39 |
| ▸ | TLL2 | Q9Y6L7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4290877 | 0.92 | GRIK1 (0.43) | — | |
| SCHEMBL7879161 | 0.92 | GRIK1 (0.43) | — | |
| SCHEMBL7873373 | 0.88 | LTB4R (0.44) | — | |
| SCHEMBL7876532 | 0.87 | LTB4R (0.46) | — | |
| SCHEMBL7946312 | 0.87 | DPP4 (0.38) | FDFT1FFAR1 | |
| SCHEMBL7874835 | 0.87 | FFAR1 (0.44) | FDFT1MMP12MMP2MMP9MMP13 | |
| SCHEMBL7431816 | 0.86 | PPARA (0.47) | HDAC2HDAC1 | |
| SCHEMBL7876539 | 0.84 | SMN1; SMN2 (0.46) | — | |
| SCHEMBL7879203 | 0.84 | LMNA (0.41) | HDAC2HDAC1 | |
| SCHEMBL7879149 | 0.83 | FDFT1 (0.41) | FDFT1MMP2FFAR1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172064-B1 | METALLOPROTEASE INHIBITOR; ANTIARTHRITIC AGENTS, ANTIDIABETIC AGENTS; ANTITUMOR AGENTS | GLAXO WELLCOME INC. | 2001-01-09 | — | — | US | disclosed |