Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.52 |
| ▸ | HTR3A | P46098 | 6/20 | 0.43 |
| ▸ | TYK2 | P29597 | 4/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957249 | 1.00 | ELANE (0.52) | ELANEHTR3ATYK2TNFPDE4B | |
| SCHEMBL7953666 | 0.89 | ELANE (0.58) | ELANEHTR3A | |
| SCHEMBL7966469 | 0.87 | ELANE (0.56) | ELANEHTR3A | |
| SCHEMBL7954868 | 0.87 | ELANE (0.56) | ELANEHTR3A | |
| SCHEMBL7946372 | 0.86 | ELANE (0.55) | ELANEHTR3A | |
| SCHEMBL7960265 | 0.85 | ELANE (0.54) | ELANEHTR3A | |
| SCHEMBL7966421 | 0.85 | ELANE (0.54) | ELANEHTR3A | |
| SCHEMBL7954825 | 0.84 | KDM4E (0.46) | HTR3ATYK2 | |
| SCHEMBL7946367 | 0.84 | KDM4E (0.46) | HTR3ATYK2 | |
| SCHEMBL7966257 | 0.84 | ELANE (0.53) | ELANEHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |