Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 14/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 13/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2157288 | 0.96 | MKNK1 (0.46) | MKNK1MKNK2CYP11B2 | |
| SCHEMBL7946521 | 0.89 | KMO (0.46) | MKNK1MKNK2CYP11B2 | |
| Hydrochloric Acid SCHEMBL10737389 | 0.86 | CYP11B2 (0.41) | MKNK1MKNK2CYP11B2 | |
| SCHEMBL7953705 | 0.85 | CYP2C9 (0.43) | MKNK1MKNK2CYP11B2KMT2A | |
| SCHEMBL10737507 | 0.84 | CYP11B2 (0.47) | MKNK1MKNK2CYP11B2 | |
| SCHEMBL7946664 | 0.84 | CYP11B2 (0.43) | CYP11B2 | |
| Hydrochloric Acid SCHEMBL10742608 | 0.83 | CYP2C9 (0.39) | CYP11B2 | |
| SCHEMBL10858691 | 0.82 | MKNK1 (0.45) | MKNK1MKNK2CYP11B2KMT2ARXFP1 | |
| SCHEMBL10742663 | 0.81 | MKNK1 (0.45) | MKNK1MKNK2CYP11B2KMT2A | |
| SCHEMBL7954905 | 0.81 | NR4A2 (0.46) | CYP11B2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |
| US-4584297-A | Pyrrolo[1,2-c]-1,3-thiazines | RHONE-POULENC SANTE (FR) | 1986-04-22 | — | — | US | disclosed |
| US-4546100-A | Pyrrolo[1,2-c]thiazoles useful as antithrombotic agents | RHONE-POULENC SANTE (FR) | 1985-10-08 | — | — | US | disclosed |
| US-4539400-A | Pyridin-3-yl substituted ortho-fused pyrrole derivatives | RHONE-POULENC SANTE (FR) | 1985-09-03 | — | — | US | disclosed |