Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 15/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 15/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 15/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 13/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 13/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 13/20 | 0.56 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7236381 | 0.90 | ADRA1A (0.70) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL7246471 | 0.88 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL7237807 | 0.86 | ADRA1D (0.53) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL7245135 | 0.85 | KDM4E (0.46) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL7238390 | 0.84 | ADRA1A (0.60) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL7240716 | 0.83 | ADRA1A (0.72) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL7955897 | 0.83 | ADRA1A (0.68) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL7955959 | 0.81 | ADRA1A (0.67) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL7952472 | 0.79 | ADRA1A (0.69) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL7954704 | 0.77 | ADRA1A (0.67) | ADRA1DADRA1AADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310076-B1 | TREATING BENIGN PROSTATIC HYPERPLASIA, LOWERING INTRAOCULAR PRESSURE, INHIBITING CHOLESTEROL SYNTHESIS, TREATING DISEASES MEDIATED BY ALPHA-1 RECEPTORS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-10-30 | — | — | US | disclosed |
| US-6211198-B1 | BENIGN PROSTATE HYPERPLASIA; INTRAOCULAR PRESSURE; HYPOTENSIVE AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-04-03 | — | — | US | disclosed |
| WO-1994022829-A2 | DIHYDROPYRIDINES AND NEW USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1994-10-13 | — | — | WO | disclosed |