Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | DCK | P27707 | 1/20 | 0.34 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2897755 | 0.79 | SMN1; SMN2 (0.55) | SLC6A2SLC6A4SLC6A3HPGDAR | |
| SCHEMBL5023935 | 0.77 | KDM4E (0.51) | SLC6A2SLC6A4SLC6A3L3MBTL1MAPT | |
| SCHEMBL1711665 | 0.76 | MEN1 (0.53) | SLC6A2SLC6A3L3MBTL1MAPTKDM4E | |
| SCHEMBL693585 | 0.76 | KMT2A (0.49) | SLC6A2SLC6A4SLC6A3HPGD | |
| SCHEMBL2266338 | 0.75 | SLC6A4 (0.47) | SLC6A2SLC6A4SLC6A3L3MBTL1MAPT | |
| SCHEMBL2902921 | 0.73 | KDM4E (0.41) | SLC6A4L3MBTL1MAPTNPSR1HPGD | |
| SCHEMBL2901270 | 0.73 | MAP4K4 (0.46) | HPGDDCKTSHRSLC22A12 | |
| SCHEMBL5361562 | 0.73 | MAP4K4 (0.44) | KDM4E | |
| SCHEMBL475213 | 0.73 | L3MBTL1 (0.57) | SLC6A2SLC6A4SLC6A3L3MBTL1MAPT | |
| SCHEMBL2751860 | 0.72 | SMN1; SMN2 (0.41) | L3MBTL1MAPTKDM4ETSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235758-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-22 | — | — | US | disclosed |
| EP-0808312-B1 | INDOLE DERIVATIVES AS 5-HT RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM PLC (GB) | 2000-11-02 | — | — | EP | disclosed |
| US-5990133-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS ANXIETY OR DEPRESSION | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |