Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | TYMP | P19971 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12880138 | 0.81 | MAPT (0.75) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL6287732 | 0.81 | MAPT (0.48) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL6908092 | 0.81 | MAPT (0.48) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL9874312 | 0.81 | MAPT (0.48) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL29512056 | 0.81 | MAPT (0.75) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| Bromide SCHEMBL7960862 | 0.80 | MAPT (0.47) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL9874308 | 0.80 | MAPT (0.47) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL3696336 | 0.79 | MAPT (0.50) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL23581815 | 0.77 | MAPT (0.44) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL12223406 | 0.77 | ALOX5 (0.57) | MAPTALDH1A1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6031103-A | Process for manufacturing 1-[3-cyclopentyl -2(R)-[1(R)-hydroxycarbamoyl)-2-(3, 4, 4-trimethyl -2, 5-D ioxo-1-imidazolidinyl) ethyl] propionyl] piperidine | HOFFMANN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | claimed |
| US-6172238-B1 | Process for manufacturing 1-[3-cyclopentyl-2(R)-[1(R)-hydroxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]propionyl]piperidine | HOFFMANN-LA ROCHE INC. | 2001-01-09 | — | — | US | disclosed |
| JP-2000063358-A | CHIRAL SUCCINIC ACID DERIVATIVE | F HOFFMANN LA ROCHE AG | 2000-02-29 | — | — | JP | disclosed |
| US-6031103-A | Process for manufacturing 1-[3-cyclopentyl -2(R)-[1(R)-hydroxycarbamoyl)-2-(3, 4, 4-trimethyl -2, 5-D ioxo-1-imidazolidinyl) ethyl] propionyl] piperidine | HOFFMANN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | disclosed |